People carrying the germ-line MSH6 mutation are at high risk by age 80 years for colorectal and endometrial cancers and any cancer associated with Lynch syndrome, according to a new study published online December 22 in the Journal of the National Cancer Institute...

Charles Sherr, M.D., Ph.D., co-chair of Genetics and Tumor Cell Biology at St. Jude Children's Research Hospital and a Howard Hughes Medical Institute Investigator, has been awarded the distinction of American Association for the Advancement of Science (AAAS) Fellow. AAAS is the world's largest general scientific society...

Gail Entner Sonenshein, PhD, a professor in the department of biochemistry at Boston University School of Medicine, and director of the School's Program in Research on Women's Health, has been awarded the distinction of AAAS Fellow. Election as a Fellow is an honor bestowed upon AAAS members by their peers...

UroToday.com - The impact of body mass index (BMI) on PSA levels is small according to a report by Dr. Stacy Loeb and colleagues from Johns Hopkins University and the National Institute on Aging that appears in the December, 2009 online edition of the Journal of Urology. The problem is defined by the fact that in 2001-2002, 65...

UroToday.com - Ours is a retrospective review of patients who underwent open retroperitoneal lymph node dissection between 2001-2008...

UroToday.com - Management of advanced renal cell carcinoma remains an extremely difficult scenario in urologic oncology. In the setting of non-metastatic renal carcinoma with tumor thrombus invading into the inferior vena cava, complete extirpirative surgery, including thrombectomy and nephrectomy has been shown to have acceptable oncologic and long-term outcomes for the patients [1, 2]...

Concentrations of the biomarkers CA125, human epididymis protein 4 (HE4), and mesothelin began to rise 3 years before clinical diagnosis of ovarian cancer, according to a new study published online December 30 in the Journal of the National Cancer Institute. However, the biomarkers became substantially elevated only in the last year prior to diagnosis...

The prevalence of left-sided advanced colorectal neoplasms was lower in participants in a community setting, but not right-sided advanced neoplams, who had received a colonoscopy in the preceding 10 years, according to a new study published online December 30 in the Journal of the National Cancer Institute...

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Intravenous Administration of Antineoplastic Drugs: Review of Basics and What's New in 2009.

J Infus Nurs. 2009 Sep-Oct;32(5):276-85

Authors: Wilkes G

Today, newer treatment regimens combine chemotherapy with targeted therapy, based on an improved understanding of cancer pathophysiology. New diagnostic testing with microarray technology is helping to identify mutational sequences in patient tumors, so individualized treatment of cancer will occur during our lifetime. The administration of IV antineoplastic drugs continues to be an important role of infusion nurses. In addition, this therapy has also found a niche in the treatment of nonmalignant conditions such as rheumatoid arthritis. This article reviews the fundamentals of administration of IV antineoplastic drugs and current issues and trends.

PMID: 20038877 [PubMed - in process]

Related Articles

Putting evidence into practice: prevention and management of bleeding in patients with cancer.

Clin J Oncol Nurs. 2009 Oct;13(5):573-83

Authors: Damron BH, Brant JM, Belansky HB, Friend PJ, Samsonow S, Schaal A

The primary cause of bleeding in patients with cancer is thrombocytopenia and it commonly is attributed to myelosuppressive chemotherapy, radiation therapy, or bone marrow infiltration of the malignancy. Oncology nurses have a critical role to play in the prevention and management of bleeding in patients with cancer. As part of an Oncology Nursing Society Putting Evidence Into Practice (PEP) project team, the authors of this article reviewed the current literature to identify effective interventions in the prevention and management of bleeding in patients with cancer. The authors evaluated research studies conducted since 1991, current clinical practice guidelines, and systematic reviews. The literature was reviewed, synthesized, and developed into evidence tables that were ultimately published in a PEP card. All data were reviewed by experts in the field of thrombocytopenia. The Prevention of Bleeding PEP card was unveiled at the 8th Annual Institutes of Learning in November 2007.

PMID: 19793714 [PubMed - indexed for MEDLINE]

US researchers have discovered two genes that appear to work together as master switches to turn on hundreds of other genes that drive the most aggressive forms of brain cancer: they hope their findings will help develop completely new approaches to treat these incurable tumors...

A promising cancer drug, first discovered in a mushroom commonly used in Chinese medicine, could be made more effective thanks to researchers who have discovered how the drug works. The research is funded by the Biotechnology and Biological Sciences Research Council and was carried out at The University of Nottingham...

Facet Biotech Corporation (NASDAQ: FACT) and Bristol-Myers Squibb Company (NYSE: BMY) announced that potentially promising data from a Phase I/II study of elotuzumab, an investigational humanized antibody being studied for the treatment of relapsed multiple myeloma (MM), were presented today at the American Society of Hematology (ASH) 2009 Annual Meeting in New Orleans...

UroToday.com - Detection of PSA with increasing sensitivity may enhance several aspects of disease monitoring. Micro- and nanoelectromechanical systems (MEMS and NEMS) are new devices for detection of infectious agents and disease biomarkers...

UroToday.com - The incidence of testicular cancer (TC) and Hodgkin lymphoma (HL) has increased recently. Although improved chemotherapeutic regimens have augmented survival in men with these malignancies, they are associated with a negative impact on reproductive health, including a decrease in fertilization rate and an increase in embryo loss...

What you need to know about skin cancer and sun. What are the dangers? What presautions do you need to take?

In a shift in thinking about why cancer occurs and how to stop it, researchers are looking to a cancer’s surroundings.

Scientists discover the workings of a promising cancer drug, first discovered in a rare kind of wild mushroom.

The use of asbestos fibers is now banned in France. However, they could continue to wreak havoc for a long time. 30 000 new cancer cases are due each year on this product in developed countries. And many other parts of the world may be affected in turn.

Our group has been able utilize aptamers to impede the metastatic potential in MDA-MB231 breast cancer, as well as slow the local tumor 3-D growth rate. MDA-MB231 breast tumor cells use a secreted phosphoprotein, osteopontin (OPN), to mediate migration, local invasion, angiogenesis, cell colony formation, and metastatic potential.

An introduction to the use of gene therapy in the treatment of prostate cancer, specifically looking at how gene expression can be specifically targeted in prostate tumor cells.

With the diagnosis of pancreatic cancer, your chance for long term survival is not very hopeful. Because the pancreas is located deep in the abdom..., D. P. Noe

Breast cancer survivors have been getting bum advice. For decades, many doctors warned that lifting weights or even heavy groceries could cause painful arm swelling. New research shows that weight training actually helps prevent this problem.

Chemotherapy kills fast growing cancer cells and it also can affect the healthy cells in your body. Chemotherapy targets healthy cells in the lini..., D. P. Noe

Malignant pleural mesothelioma is relatively rare in frequency but is one of the intractable cancers linked with asbestos exposure. Malignant pleural mesothelioma is a solid tumor developed in the thoracic cavity and extends into the vicinity organs to disturb the functions of vital organs such as lungs, large vessels and heart.

Are you aware that if everyone would get screened for colon cancer that they could almost eliminate this disease? Screening is the key to finding ..., D. P. Noe

...breast cancer is known to be one of the most common cancers occurring in women. In fact, some scientific studies and research has shown that one o

Versacchi has been in the forefront helping people from suffering breast cancers with providing breast prosthetics,breast radiotherapy,breast chemotherapy treatments and mastectomy breast forms in Ireland.

End of 2009 in Cytogenetics and Cancer Research Blog

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